There are fewer thousand cups in the wine, but don't say 'thousand cups'. Some people may fall down with a cup. In the emergency department of the hospital, there have been many doctors who have been treated for alcoholism. Serious drunkenness may also endanger life. Why some people 'Thousands of cups are not drunk', some people fall down with a cup? This is largely related to genes.
Wine can hurt your life
Alcoholism caused by heavy drinking can directly lead to the death of drinkers. Alcohol can inhibit the respiratory center of the medulla, causing respiratory arrest. In addition, blood sugar drop may also be a fatal factor.
Long-term heavy drinking can cause various chronic diseases such as fatty liver, cirrhosis, gastric ulcer, nervous system damage, cerebral cortical atrophy, etc.
Why do you drink alcohol?
Alcohol is converted into acetaldehyde by the action of alcohol dehydrogenase in the human body. The acetaldehyde is decomposed by acetaldehyde dehydrogenase to become acetic acid, thereby hangover.
If the activity of acetaldehyde dehydrogenase decreases, acetaldehyde can also be reduced to ethanol by alcohol dehydrogenase, thereby maintaining a high concentration of ethanol and acetaldehyde, causing nausea, vomiting, coma and other drunkenness symptoms after drinking.
When the concentration of ethanol in the blood is between 0.05% and 0.1%, people start to get drunk; when they reach 0.3%, people will be unclear and gait, which is what we often say is drunk; if it reaches 0.7%, people It is possible to die.
And acetaldehyde is a carcinogen, long-term high concentration of acetaldehyde can induce cancer such as esophageal cancer.
The tolerance to ethanol is very different from person to person.
In the past, we didn't know the specific reasons. I thought everyone should have the same amount of alcohol. Whoever said that they can't drink alcohol is pretending. However, the development of science explains the reason. Some people have mutations in their genes. Drinking means losing health or early. Die.
Alcohol dehydrogenase ADH1B gene mutation
When alcohol enters the body, it is converted to acetaldehyde. If the gene is mutated, the rate of conversion of alcohol is slow, and it is difficult for the body to metabolize alcohol.
Among Chinese, AA gene is 57.8%. This kind of person is easy to have headache and uncomfortable when drinking a small amount of alcohol; 37.8% of AG genes, this kind of person can drink more wine; GF gene is 4.4%, this kind of person is addicted Wine is like life, drink too much and not drunk.
However, for people with GG gene, the risk of alcohol-related esophageal cancer is 4.09 times higher than that of others due to excessive drinking; the risk of alcohol-induced colon cancer is 1.75 times higher than that of others; this kind of human telomere is more Short, more prone to premature aging, and prone to aging-related diseases. Therefore, such people should abstain from alcohol or drink as little as possible.
Aldehyde dehydrogenase ALDH2 gene mutation
42.4% of the Chinese people metabolized the acetaldehyde acetaldehyde dehydrogenase gene (ALDH2) to produce partial gene mutation (GA), the enzyme activity decreased by about 45%; in another 7.1% of the Chinese, the gene was completely mutated (AA ), the enzyme activity decreased by 90%, the ability to substantially lose the metabolic toxicity of acetaldehyde.
In addition, 50.5% of Chinese, ALDH2 (GG) gene is normal, can normally metabolize acetaldehyde.
For those with complete ALDH2 mutations, the risk of alcohol-related colon cancer is about 2 times higher than that of others, and the risk of alcohol-related esophageal cancer is 4.13 times higher than that of others, and cirrhosis is prone to occur.
Usually, people who drink more than 100 grams (200 ml of 50-degree white spirit) every day, the liver will be obviously damaged, liver function abnormalities, liver cirrhosis and so on.
Partial and complete mutations in the ALDH2 gene, even with a small amount of alcohol, are more severe in liver damage than those with normal ALDH2 gene in drinking 100 grams of alcohol.
