According to reports, 'organ microchip' is an emerging research field in the international medical community. Its principle is to use microchips that mimic the conditions of human blood circulation as a carrier, and to establish various types of 'bionic micro-organs' to achieve some functions of human organs. One of the major advantages of 'organ microchips' is that they can be run in vitro, allowing researchers to observe drug reactions instead of some living experiments.
In this study, the research group immobilized the enzymes involved in alcohol metabolism on the coding carrier and used microfluidic electrospray to encapsulate them into microcapsules to form a liver-like biomimetic tandem enzyme-catalyzed system. The experimental results showed that this The liver chip' exhibits a good initial metabolism of alcohol.
'The liver is an important detoxification organ for the human body. The development of a 'liver chip' with detoxification function is an important research direction for the 'organ microchip'. ' Zhao Yuanjin said that researchers can use the 'liver chip' to develop antidote drugs or health products in the future. Even developed artificial organs that can partially replace liver function.
Relevant results were recently published in the "Science Progress" sub-scientific.