| According to foreign media report New Atlas, in an initiative that may lead to artificial transplant organs and complex regenerative therapies, a team at the University of California, Los Angeles, led by biological engineer Ali Khademhosseini, developed a method for printing complex organisms using multiple materials. New technologies organized. The team uses a specially modified 3D printer and is expected to create therapeutic biomaterials on demand in the future.  Organ transplants and other advanced tissue treatments face seemingly insurmountable bottlenecks. There are only a limited number of organ donors or other sources of biological material, and even under the best conditions, organs and tissues are not fully compatible with receptors. , and may not be suitable for the purpose. Ideally, bioengineers want to completely bypass conventional sources and grow organs and tissues in the laboratory. This not only provides the medical community with an unlimited amount of healthy, sterile materials, but also allows Doctors and surgeons make biomaterials according to their requirements. The trouble is that living tissue is very complex with many different types of cells, blood vessels, nerves and mechanical structures. Try to grow a heart in a petri dish and mix some of the cardiomyocytes with nutrients. What you will get is Soon it will stop the dividing cells. Another approach is to create a scaffold using biocompatible materials such as poly(ethylene glycol) polyethylene glycol diacrylate (PEGDA) and gelatin-methacryloyl (GelMA). This scaffold mimics the structure of a living tissue. Like the cartilage in the baby's body. At birth, most of the baby's bones are cartilage, but as it grows and matures, bone tissue will be replaced. In artificial tissues, stem cells are introduced, which grow into the scaffold. And replace it. One technique for creating these stents is called autostereoscopic lithography. This is a light-based process in which a hydrogel mixed with stem cells is placed along with a 3D printer, and when the light beam causes the formation of molecular bonds, Rubber hardening. The bioprinter designed by Khademhosseini is based on this technology, but it also includes a custom microfluidic chip on the size and shape of the microchip. This has multiple inlets, so it can be printed using multiple cell injection materials at a time. Researchers at the University of Los Angeles have stated that during operation, the automatic mirror creates a pattern for each layer of the object being printed while the light is able to coagulate the gel. Currently, the printer uses four types of 'bio-ink' but this number can be expanded . So far, printers have been used to create simple shapes, 3D simulations of muscle tissue and musculoskeletal connective tissue, and false tumors with blood vessels. In addition, these structures have been implanted in rats without rejection. Khademhosseini stated: 'The organizational structure is very complex, so in order to design a functional version of the manual, we must recreate their complexity. We provide a new approach by building complex biocompatible structures made of different materials. to fulfill. ' The study was funded by the United States Naval Research Office and the National Institutes of Health, and published in the magazine "Advanced Materials." |
 |
|