Don’t worry, it will die! In the face of cardiovascular diseases, 'morning guards' and 'night owls' are treated equally! If the all-cause death rate (including bizarre deaths), the 'night owl' enjoys its exclusive favor! Mental illness, diabetes, neurological dysfunction, gastrointestinal dysfunction, respiratory dysfunction, take away.
However, if your mother reminds you to go to bed, you can also use her tongue to give her genetics and tell her that you are between the ages of 60 and 70. It is the most dangerous --- the insurance ---.
Luxury toilet kill time enjoy version:
Quiver! Night owls, "International Time Biology" magazine in April 2018 thrown out a heavyweight article "British biological sample database, the relationship between work and morbidity and mortality", scared this night owls are plasmolysis Now.
Are you ignorant of loneliness or life? Today, let the world's largest biological sample database - the British biological sample database - this includes more than 430,000 people, aged 38-73 years old, followed up for 6.5 years In the meantime, a large-scale forward-looking study of '10,534 people died' to hammer it. (Suddenly a bit gloomy...)
The main purpose of this study is to understand the relationship between type of work and all-cause mortality (including all-cause mortality) and mortality from cardiovascular disease. The details of the death certificate will be provided to the UK Biobank, the main cause of death will be Recorded by professional trainees. (Here is a deep admiration. After all, we in the East are too jealous of life and death. If the telephone line can transmit anger, follow-up calls to the families of the deceased are enough to blow up the earth into two dimensions.)
In the bibliography, the author stunned Mimi proudly: "The type of sleep and preference for doing things at night has long been proven and many complications (high-probability metabolic disorders, cardiovascular diseases, psychiatric Symptoms are closely related, but so far, no one has! No one! Knowing that there is no relationship between type of work and death risk ah ha ha ha ha ha. And we, not only in this large cohort study to see 'night work and death The hypothesis that the rate is higher does not hold, but also the way the general disease is compared in the rest groups.
(I'm sorry to have tried to figure out the author, the real author is very serious...)
Excluding the questionnaire 'nothingness', and the lack of necessary 'covariates', eventually screened 433,268 people to enter the survey (55.7% were women, although later found that 'gender' had little effect on the results).
The 'covariate', as an independent variable, cannot be manipulated by the experimenter, but it still affects the experimental results. For example, we study how much the relationship between day and night is related to mortality, then the 'age' of the participants is one of the 'covariates'. Because of the age, it is inevitable that the risk of “leadership” (“death” is too large). When doing research, it is necessary to control the role of covariates so as not to confuse the relationship between the subjects.
The covariates of this experiment were: age, sex, ethnicity, smoking status, body fat percentage, sleep duration, comorbidities, socioeconomic status (statistical, socioeconomic status, risk ratio (HR)> 1, prove it is All-cause mortality and cardiovascular mortality risk factors! Satisfy the old iron!)
The people who are recruited through a self-questionnaire survey answer a question to group: Do you think you are?
What kind of conditions a person must meet, such as a clear morning person, he must follow the 'morning behavior': early sleep and early rise, and the spirit of the day, physiological peaks appear in the morning. A clear morning defender' !
A clear evening person follows the 'night behavior': sleep late and get up late, and the best performance of the day occurs late at night or on the tail of the day. The 'night owl' is a clear one!
A person who is basically a morning person is a person who puts more weight in the morning than in the evening. And 'essentially an evening person' is just the opposite.
This study used only one question to assess the type of work routine. The MEQ (the circadian rhythm scale that was previously mainly applied, was cited 1039 times as of 2012, and can be imagined as authoritative), and the Munich Worksheet requires After answering a few questions, it is possible to assess the participant's behavioral classification. Obviously this is a potential weakness in the entire study, but in fact it is exactly the same as the most central and most valuable issue in the MEQ questionnaire. The possibility is very small ~ (How suddenly feel MEQ is a bit embarrassing and silly ...)
Here is the result of our much-anticipated!
Of the 433,268 people, 27% were clear 'morning guards', 35% were basic 'morning guards', 28% were basic 'night owls', and 9% were clear 'night owls'.
Have to sigh 'Ginger is still old spicy!', Clear 'morning guards', tend to be older on average, and most are female and non-smokers.
In contrast, the group of clear 'night owls' who are 'dead to death' are often young people, old people, white people, smokers, and no cardiovascular diseases (unforgetable commotion, favored and fearless?) , And diabetes, neurological dysfunction, respiratory dysfunction, gastrointestinal dysfunction or mental disorders (muffled to death?) Geese. It is no wonder that the "night owl" can be seen as a sign of puberty tail. (And so on... ...I suddenly thought of my 60-year-old man who loves staying up late...)
Knocking on blackboards focuses on: Clearly 'night owls' significantly increase the likelihood of each type of comorbidity than clear 'early guardians', most likely psychiatric symptoms. (OR1.94, OR The odds ratio, greater than one, is positively correlated with the disease, indicating that this factor may be a risk factor for the disease; less than one is negatively related to the disease, indicating that this factor may be a protective factor for the disease; equal to one is associated with the disease wood)
In 2016, it was studied. Compared with the “guardians of the morning,” the relationship between the most ambiguous and early “night owls” and “physical emotion disorder” and “positive emotions” has a greater impact on interpersonal relationships. .
Can't understand?
“Depression” Find out about friends! Stay up late for college students to become fragile and suffer from 'bipolar disorder'. Amish adults suffer from 'seasonal mood disorders' in community samples and are also prevalent. In clinical specimens, adults and college students are increasingly associated with depressive symptoms.
At the same time, however, the 'morning guard' was proved to be a strong positive factor in the face of depression and mental health.
The next order of comorbidities was: diabetes (OR1.30), neurological dysfunction (OR1.25), gastrointestinal dysfunction (OR1.23), respiratory dysfunction (OR1.22)
After adjustment of age and gender, the relationship between the type of work and the general disease, in which the type of daily rest is referenced to a clear 'morning guardian' as both a pseudo-continuous four-level variable and a category variable.
Originally wanted to find a map to explain the relationship between 'day and night' and 'diabetes'. The results of the literature were too intimate, and added three other hazards of day and night, so that this night the cats feel at ease.
1. Insufficiency of insulin sensitivity due to impaired glucose tolerance, and insufficient islet beta cell response
2. Elevated inflammatory markers
3. Raise the mean arterial pressure
4. Reduce energy consumption
Isn't it a bit embarrassing! Originally came in to look at 'Will the day and night die in the end'? How do you get out so much to make a moth? Watch out for the brothers! This is not groundless!!
In 2015, a study on the effects of the circadian rhythm disrupting the metabolic health of the myocardium not only reviewed the cardiometabolism investigation after the “shifting child”, but also introduced five experimental studies of the “sweet night cat grief and see the night owl crying”. .
■ The first experiment:
Ten Warriors (health volunteers) signed a 10-day 28-hour desynchronization protocol (force them to cross 28 hours a day in these ten days), eat the same and equal amounts of food.
It was found that when the maximum circadian rhythm was out of balance, 3 of the 8 participants had reached the pre-diabetic stage. However, insulin levels also rose, and they also increased by 22%!
In other words, when our body's only blood sugar-lowering hormone, insulin, goes up, the blood sugar that should have been lowered in one fell swoop! Not only does it rise, but it also reaches prediabetes.
This also reflects one thing: Insulin-producing islet Bate cells are not activated sufficiently. (Like class, there may be some old irons still sleeping! It is a truth!)
Moreover, the cortisol circadian rhythm is reversed.
Cortisol classmates, as a hormone that allows us to be prepared for the new day, are very important. The early morning guards have a high level of cortisol hormones in the body and can also explain why they are better than Night owls feel more active when they are awake.
This is reversed! It turns out that when we are awake, it rises, when we fall asleep, it goes down! Now it becomes asleep, it rises, and when awake, it goes down. This cortisol classmate is closely related to blood sugar, it can be Decomposition of glycogen into sugar, but also promote gluconeogenesis (a simple understanding: the thing that is not sugar into sugar), this type of plug-in (cheat) type of behavior, low blood sugar, dry?
Also! No! End!!
The level of leptin decreased by 17% after the circadian rhythm was destroyed. Leptin is the signal to adjust 'satiating' when eating, and it also promotes the release of dopamine.
Falling down to explain why? Eat too much ah students! Fat ---> high blood sugar ---> dopamine is not secret ---> depression!
■ The second experiment:
The Warriors not only signed a 28-hour forced to synchronize protocol, but also was lost! Heart! Disease! Kuang! Limits sleeping only 5.6 hours per day, (but it is said that this is a frequent experience of the students in the shift, as a clinical Workers, I agree with the wall) The experiment lasted for three weeks.
Although the Warriors have a young and old age group, there is no difference in the results of this cruel experiment. Fasting blood glucose levels increased by 8% and postprandial blood glucose levels increased by 14%. This time the estimated islets have跪 跪 跪: Fasting and postprandial insulin levels were significantly reduced by 12% and 27%, respectively.
At the same time, resting metabolism also decreased by 8%.
What are the concepts of resting metabolism?
A lazy person's weight-loss tool ah ah ah! When we are not moving, our body is also consuming energy, but now it consumes less, naturally it is fat.
■ Third experiment:
The Warriors were restricted for 8 days just as they were, but they were divided into two groups. The first group slept for 5 hours in 8 days. The second group (day and night disorders group) started on the fourth day and was able to lie in bed for 8.5 hours.
As a result, these two groups of insulin sensitivity all decreased significantly (high blood sugar is also too lazy to control), and the male warriors' insulin sensitivity is reduced by a factor of 2. (For the male warrior alone, why? Because the female warrior who dared to do such an experiment of zuo We are too few! Statistics don't come out.)
The inflammatory marker C-reactive protein, although increased in both groups, increased significantly in the second group.
■ The fourth experiment:
14 Warriors stayed in the hospital for 6 days to simulate the life of a shift:
One night shift can only sleep for 2 hours, then for two days (to sleep 8 hours), and then night shift... (clinical dog panic face: 'Isn't it imitating me?')
As a result, in the first night shift, the total energy consumption in the body increased by 4%, and then from the second time, the total energy consumption in the body began to decline! (Fat start!) And a bug (very horrible loophole) was generated. : Reduced calories after eating!
What does this mean?
It means that it takes more food to reach the calories needed by the body, while leptin is also reduced. That means that at the same time it is still not enough to eat, although the overall appetite is reduced, but there is no egg! (An increasingly clinically fat person Evolutionary experience!)
The last experiment was very straightforward: The postprandial blood sugar was 17% higher in the evening than in the morning. After circadian rhythm disorder, it not only increased the postprandial blood glucose level, but also reduced the insulin sensitivity. Simply put, it was: Sugar is more than a series of terrible factors in addition to raw materials that can be converted into fat!
Having finished the complications, I finally came to the core content of this article: What is the undefinable relationship between 'day and night' and 'dead'?
It turns out that the type of rest and the type of death actually have a true connection. But it is also related to 'all-cause mortality' and 'cardiovascular disease-related mortality'. However, there is no statistical significance at the moment. In fact, it is not recognized by the academic community.
A clear 'night owl' is 10% more likely than a clear 'morning guard' with all-cause mortality.
At present, it is unanimously held that the 'terror encounter' of the night owls is due to the disconnection of their own biological clocks and social activities, resulting in a biological rhythm disorder. After all, experiments have shown that intentionally induced disturbances in work order can lead to glucose metabolism damage and genetic abnormalities. The process of cyclical expression is severely impaired and mood disorders are common, and night owls generally feel that they have a social time difference since the end of the week on weekends. This jet lag not only causes a higher body fat rate, but also has a greater effect on myocardial metabolism. Very adverse effect.
Clear 'morning guards' have a lower risk of death in the face of all-cause deaths!
The middle two types were not found to have a definite connection with the mortality rate. Fortunately, those who chose 'I don't know' did not cause any deviation from the actual results.
For players in the 63-73 age group, the type of work routine is significantly associated with all-cause mortality.
This is to give us courage instead of Liang Jingru.
When you face Dad and Mom urges you to sleep, you can also say with great care: 'The research in the SCI said that the mortality rate of your age is significantly related to your daily schedule. 37-52 and 53-62 There is no relationship between the age groups ('high-risk behavior, do not imitate...)
If you don't feel cool enough, then there is another bug that you know:
Circadian rhythm is closely related to gene regulation. Moreover, studies have shown that some features of sleep are highly inherited, and studies of twins have also shown that overall, circadian rhythms have a high heritability of 21%-52%!
Although the correlation between circadian rhythm and genetics does not currently have a solid hammer, several gene types of the PER gene have been determined to have a clear relationship with biological rhythms. However, circadian rhythm is a complex phenotype that requires multiple gene regulation. , so you still need to increase research efforts to be conclusive.
But if you really say something to your parents like the above, you can also throw a pan at the time of the moment: "Why is it why I stay up late? It's not because you're genetic!"
In fact, even if there is no article that really hammers 'life or death,' many of the dangerous behaviors caused by staying up late will indirectly indicate to us that it is not a good thing.
For example, the type of 'night owl' is closely related to the legally refreshing substances (smoke, alcohol, coffee), and even illegal substances (drugs: marijuana, ecstasy, cocaine).
The night owls wanted to use them to keep themselves awake in the morning (because according to their own biological clock, they should be several hours later than the social clock of the community), and they would taste the sweetness when they started using them. Addictive behavior. But more terrible than the risk of addiction are the short-term consequences of these bad guys, such as accidents, unwanted pregnancies, fights, etc.
What makes people look distorted is that 'morning of the morning' is almost a protective factor in all of the above events.
Although the authors of the literature are very humble, they say that the results of the study so far may not be widely recognized worldwide.
However, we have devoted ourselves to the study of biological rhythms. We have worked hard to issue articles, set out a series of impact factors, etc., just to make our next generation step on their predecessors. As far as reading, so much better, it's better to be in the teen stage (proved to be the most effective) or now, to start improving the schedule. After all, the best time to plant a tree is ten years ago, or now.
■ Love eggs:
Foreign research shows that babies born in the winter are more likely to be 'morning guards' because of shorter winter lighting time, and babies born in the summer are more likely to be 'night owls' due to longer light hours. Asia does not apply, but it is still recommended that the exposure to light in the summer be reduced by a little while the baby in the winter is more than ~
The reason why the light is affected so much is because the magical 'melatonin' in the previous article, the late night of weakened light stimulation, will usher in its peak of secretion. If melatonin is reduced, it may lead to severe insulin resistance diabetes, There are mammary glands and prostate tumors. So try not to fall asleep in a shimmering environment at night.
Finally, the main character of the 'night owl' is more outgoing, impulsive, curious, enlightened, and more inclined to 'psychiatric' (doesn't really see the ghost of the movie, the deadly poison teacher sleeps early and wakes up like an old lady every day) Dancing...)
The 'morning guards' are more introverted, responsible, amiable, firm and emotionally stable.
In short, it was right that my mother reminded her to sleep.
If I can read these Sci early, isn't it that I'm not so fat, so ugly, so neurotic... but it's hard to imagine that if sci articles like radio traffic and TV in prime-time like the crowds of advertisements, it will be long nights Mom-style life-threatening chain-style reminder of sleep's scene surrounded by fragments...
Comrades still manage their own self!
Thanks for appreciation, send you a flower ~ ~
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