In the new study, Dr. Robin Danto, a food scientist at Cornell University, and his research team randomly divided the experimental mice into two groups. They were fed a normal diet with a fat content of 14% and a high fat diet with a fat content of 58%. High-heat foods. It was found that after 8 weeks, mice with high-fat diets gained 30% in weight, but the number of taste buds decreased by 25%. Next, the researchers conducted a closer look at the taste buds. They found that the taste buds consist of With 50 to 100 cells, these cells are constantly renewal, and they die. The average life span is about 10 days. The cell types have different effects and help to sense sweetness, sourness, saltiness, bitterness, and umami. The researchers further analyzed that In obese people, the level of tumor necrosis factor alpha (TNF-alpha, a specific inflammatory chemical) secreted directly by adipose tissue is significantly higher. The number of taste buds is particularly sensitive to obesity-induced TNF-alpha, and TNF-alpha levels Elevated means a decrease in the total number of taste buds. That is, chronic inflammation in the body caused by obesity will destroy the normal metabolism of taste bud cells, which may be the real cause of taste disorders in obese people. New research report published in The United States "Public Science Library Biology" magazine.
Dr. Dan said that obesity is one of the most common public health problems in the world and it will lead to a significant increase in the risk of some diseases. However, humans have been facing many challenges in the control and treatment of obesity. The taste buds of mice and humans are very similar. The results of the new research will point out new targets for the treatment of obesity. Previously, Dr. John Molton, a research expert in obesity at Stanford University in the United States, also found that as long as weight is reduced, taste perception will improve.
