Scientists use tiny beads to grow stem cells for biological 3D printing of cartilage

Researchers at Swinburne University in Australia have developed advanced new Biopen devices that make biological 3D printing possible. Currently they are helping to develop a small hand-held 3D printer that surgeons can use to efficiently regenerate patients with stem cells Important organizations such as bones and cartilage. Swinburne's latest project is called BioSphere, which is named after its more efficient growth of stem cells. Just like our recent similar 3D bioprinting project at Griffith University, it will be Government funding for the BioMedTech Horizons program.

Many bioprinting projects use stem cells. These cells can be extracted from individual patients and then grown in the laboratory to the specific tissue needed to repair the body. Because they contain the patient's DNA, they will relate to the surrounding health within the implanted area. The tissue is perfectly compatible, which leads to faster and more effective healing and can improve all kinds of injuries and diseases. The special hope of the new research of BioSphere is its innovative method for the growth of stem cells. It is necessary for the lack of successful treatment. With large numbers of cells, research on biological 3D printing technology is not as fast as predicted. Researchers also have no way to recover from the cells they are cultivating without damaging them.

The method of the Swinburne researchers is to use thousands of tiny polymer beads to cultivate cells. This is the name of the BioSphere project. These beads are about 0.3mm (0.01 inch) in diameter, and thousands of them will provide great Increase the surface area to grow cells on it. The researchers will implement a new light-based technology that separates them from the beads, not only can grow more cells faster, but they also do not remove during the process It may be damaged because the researchers will implement a new light-based technology.

According to Dr. Nicholas Reynolds, the project director, 'the surface of the beads will be covered with light-sensitive nanoparticles that will not affect the growth of the cells until the particles are activated by infrared light. At this point, the activated nanoparticles will gently move the cells from The beads are detached and can be easily restored for re-implantation in the injured patient. 'While the handheld 3D printing device or 'Biopen' will contain special bio-ink that injects the necessary cells. The surgeon will be able to use it where needed Place 'extract' new organization.


(All images from: Swinburne)

BioSphere Research is part of the PhD student Yashaswini Vegi project at the Biodevices ARC training center in Swinburne, in collaboration with the St. Vincent Hospital in Melbourne. This was one of 11 different projects funded by the A$35 million BioMedTech Horizons program. The program is dedicated to the development of innovations and expertise in biotechnology in Australia. It aims to promote research between different disciplines, cooperation between industry and technology sectors.

Source: China 3D Printing Network

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