| Japanese researchers use 3D bioprinted cell patches to repair damaged human aponeurosis in rats and observe 'complete tissue integration' of printed posters after a period of time. Exciting bioprinting studies pave the way for clinical trials the way.  Two Japanese researchers, Koichi Nakayama and Tomoaki Taguchi, who were responsible for implanting 3D-printed liver buds into living rats, have recently released a new study that tries to print and regenerate 3D biofilms from different parts of the body. The researchers used a Regenova 3D bioprinter from Cyfuse Biomedical to generate a large, non-scaffold tissue patch composed of human cells (human dermal fibroblasts and human umbilical vein endothelial cells) in an attempt to repair damaged human aponeurosis membranes attached to rats. The printer uses a unique cell tilting technique known as the Kenzan method. The print cell patch is approximately 20mm long, 3mm internal diameter, and 1mm wall thickness. The results show that 3D printed cell patches are very Strong elasticity, suitable for transplantation. Those rats that had been attached to the bioprint patch survived for 710 days. The investigators noticed complete tissue integration of the graft during the growth of the rats. Histology showed reconstructed muscle structure within the septum, neovascularization and nerves Regeneration of the network. Because of this, Japanese researchers stated that their findings prove that the created cell patch is a highly safe and effective treatment strategy for the repair of diaphragmatic defects, paving the way for clinical trials. Looking ahead, the researchers plan to use the new Kenzan design on larger animals (such as rabbits) to create large 5x6 cm cell patches. Source: Tiangong Society |
 |
|