The US "Protein and Cell" magazine published a breakthrough new study in Tongji University in Shanghai, said that the use of patient autologous stem cell transplantation regeneration technology can repair pulmonary fibrosis and other chronic diseases on lung injury. This new technology for stem cell transplantation for patients with chronic lung disease Successful healing brings new hope.
In this transplantation clinical trial, Professor Zuo Wei of Tongji University Medical School and his research team used adult lung stem cell transplantation technology to successfully achieve lung regeneration in humans.
Researchers obtained dozens of stem cells from the patient's bronchus, which were expanded to tens of millions of times in vitro and transplanted to lung lesions. After 3 to 6 months of proliferation, migration, and differentiation, stem cells gradually formed new alveoli and The bronchial structure, in turn, repairs and replaces damaged lung tissue.
The researchers said that autologous lung stem cell transplantation in patients with 6 interstitial lung diseases and 2 patients with bronchiectasis has demonstrated effective lung tissue repair. After the stem cell transplantation, the patient's lung ventilation capacity (breathing) Ability and 6-minute walking distance (walking ability) and stem cell repair of damaged lung tissue and other indicators have been significantly improved.
Previously, in order to verify the ability of human lung stem cells to replant, the researchers transplanted fluorescent stem cells labeled with fluorescent protein into the damaged lungs of mice. Observations 3 weeks after transplantation found that the lung fibrosis lesions in rats were Newborn human bronchial structure and alveolar replacement and 'regaining new life' are very healthy. Arterial blood gas analysis results show that the lung function of experimental rats recovers significantly.
Prof. Zuo Wei said that lung disease is the third leading cause of death after heart disease and cancer. The results of a new study in our country show that lung stem cell transplantation therapy is available for patients with pulmonary fibrosis, bronchiectasis and interstitial lung disease. Hope is the greatest. Researchers say that such chronic lung disease treatment can be overcome in 5 years.
