Toothpaste bactericidal anti-malaria ingredients

More than 500,000 people die every year from malaria worldwide, especially in Africa and South-East Asia. Although a range of drugs are being used to treat the disease, Plasmodium is becoming more resistant to these drugs and may be harder to come by Prevention and treatment.

Recently, a new study involving artificial intelligence robotic scientists at the University of Campinas in Brazil demonstrated that a bactericidal and antibacterial ingredient commonly found in cleaning products such as toothpaste, soap and detergent may be used for control Malaria parasites that are increasingly resistant.

The existing anti-malaria drug pyrimethamine, which suppresses parasite growth, targets a substance called dihydrofolate reductase (DHFR) in Plasmodium, however some P. falciparums are now resistant to this drug Especially in Africa, this time the robot 'Eve' found that a component called triclosan was able to find the target DHFR enzyme in the malaria parasite and take action to more effectively control parasite growth, The same is true for parasites that are resistant to pyrimethamine.

Lead author Elizabeth Campsland, an assistant professor at Campinas University, said: 'Our robotics colleagues found that triclosan was able to fight malaria, which has brought good news to mankind, a safety ingredient , Is capable of working against two target points in the life cycle of Plasmodium, which means that Plasmodium will have a hard time evolving resistance and in the future we may be able to use it to develop a new drug. "The research paper was published in Science Report "journal.

Toothpac was contained in toothpaste, which is used to prevent the growth of plaque and simultaneously inhibits both DHFR and ENR, an enzyme that acts on fatty acids in the liver. Thus, the researchers said , Triclosan or from the liver and blood can be two channels to control malaria parasite.


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