| Recently, collaborative research teams from Harvard Wyss Institute, JuliusWolff Institute, Berlin-Brandenburg Regenerative Therapy Center and Charité Musculoskeletal Surgery Center gathered to study 3D printing The Benefits of Titanium Mesh Stents in Implants A recent preclinical study published in Translational Medicine reports that 3D printed stents do help optimize bone regeneration in patients.  In the medical field, the treatment of large bone defects or injuries remains a thorny area.People who have severe defects in the upper or lower extremities due to infection, cancer or trauma often have to undergo amputation as it is difficult to regrow or repair more than one A little bone tissue. One existing treatment involves the manufacture of customized bone grafts from the patient's own bone tissue, although the success rate of this method is not high. According to a recent report, a customized 3D printed titanium mesh stent may be a potential solution because implants can promote and achieve natural bone regeneration. A team at the Charité Musculoskeletal Surgery Center has demonstrated that it is possible to design and manufacture customized 3D-printed stents for the treatment of large bone defects. Using CT scans of the patient's bones, the medical team can generate 3D models of the defect's bones. Based on this digital model, a custom scaffold can be 3D modeled, then sent to a mechanism that uses a laser to sinter the 3D printer and use a medical grade titanium to make the scaffold.The resulting product is a 3D printed titanium implant with its Known for its porous scaffolding structure. This 3D printed structure is crucial to promote bone regeneration because it allows the physician to fill the implant with the patient's bone tissue, growth factors and bone replacement material.It is noteworthy that the 3D printed mesh structure has been mechanically optimized, To 'further strengthen the healing process'. As Dr. Anne-Marie Pobloth, a veterinarian at the JuliusWolff Institute in Charité, explains: 'My team started using computer modeling techniques to optimize standard-size stents. Using a large animal model, we can examine its actual impact on bone regeneration Because the process of bone regeneration is very similar to that of humans, we can infer the healing of human bones. To date, the Charité Musculoskeletal Surgery Center has implanted a customized 3D printed bone scaffold into a total of 19 patients, all of which have shown promising results. The 3D printed implants themselves are characterized by a honeycomb structure constructed to form small channels that promote and guide bone regeneration.The important thing that researchers have found is that they can change the stiffness of the implant by changing the diameter of the pillars of the honeycomb structure , So that they can test the effectiveness of different stiffness. Dr. GeorgN.Nuda, director of the JuliusWolff Biomechanics and Skeletal Muscle Regeneration Center, said: 'In our opinion, bone regeneration will vary depending on the hardness of the stent implanted so in order to study the effect of mechanical stimulation during bone regeneration we used four Test group, to accept different stiffness implants. The results of these tests show that softer implants are more conducive to bone regeneration, Dr. PFPhilipp Schwabe, a traumatic surgeon, explains: 'After three months of research radiological evidence showed that soft implants produced faster than hard implants The mechanical stimulation of the response to bone growth faster. In fact, researchers found that the biomechanical properties of 3D printed implants directly affect the amount of bone formation and the quality of regenerated bone. Based on this situation, the team is designing and producing 3D printing technology Of the soft, mechanically optimized titanium mesh stent.The team says its technology can even be used to treat spine, oral and maxillofacial defects. Source: 3D Tiger |
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