Recently, the National Natural Science Foundation of China presided over the major national scientific research and equipment project development and acceptance of a special project acceptance meeting held in Beijing.Dalian Institute of Chemistry Li Chan academician, Feng Zhaochi team led by researcher completed the "electric field, magnetic field modulation shortwave chiral Raman Spectrometer Development 'has been specially approved by Results and achieved excellent results. This progress was also published by Applied Spectroscopy (2017, 71 (9), 2211-2217). The successful development of the world's first 457nm laser as the excitation light source of short wavelength Chiral Raman spectrometer.
Chirality is one of the basic properties in nature, and the research on chiral molecules is of great significance in the fields of life sciences, drug synthesis and asymmetric catalysis, among which the absolute configuration identification of chiral molecules is a challenge in the scientific community. Chiral Raman spectroscopy is a new spectroscopic method for the characterization of chiral molecular structures. Since this method does not require sample crystallization, it can directly identify the absolute configuration of the chiral sample in the solution phase. Therefore, it has been widely accepted by academia and industry However, the intrinsic signal of chiral Raman spectroscopy is very weak, which is 3 to 7 orders of magnitude weaker than that of conventional spectroscopic signals, so it is very challenging to detect chiral Raman signal experimentally.The team of researchers in many years of UV Raman spectroscopy instrument based on the proposed short wavelength chiral Raman spectroscopy research ideas, based on avoiding the electronic state absorption and to avoid fluorescence interference two basic principles of analysis, optimization selected for the chiral Raman spectroscopy 457nm Laser as a light source, with the relevant spectroscopy company at home and abroad, the successful development of the world's first short wavelength chiral Raman spectrometer, but also to fill our hands Sexual Raman spectroscopy gaps.
After the successful development of the instrument, the 457nm short wavelength chiral Raman spectroscopy seminar was held at the 19th National Light Scattering Conference held recently. Six domestic experts in analytical chemistry, asymmetric synthesis and drug research Experts, experts in the field of Raman spectroscopy and North China Pharmaceutical Group and other chiral drugs, technical director of nearly 30 experts attended the meeting.Expert participants listened to the project leader in charge of summary report, the development of other members of the project team Work introduction and on-site testing experts, conducted an in-depth discussion.At the end of the meeting experts believe that: the first successful international development of 457nm short wavelength chiral Raman spectrometer, a substantial increase in signal-to-noise ratio, the recording time by the number Hours to tens of minutes, the test sample requires from pure compounds to 10%, the chiral Raman instrument performance reached a new height, but also to fill our country in the chiral Raman spectroscopy equipment gap. The short wavelength chiral Raman spectrometer was engineered as soon as possible and is expected to be used in chiral molecular identification, drug synthesis and identification, asymmetric catalysis and The study of macromolecules plays an important role.