| Recently, a collaborative research team from the Wyss Institute in Harvard, the Julius Wolff Institute, the Berlin-Brandenburg Regenerative Therapy Center and the Charité Musculoskeletal Surgery Center came together to study the benefits of 3D printed titanium mesh stents in implants A recent preclinical study published in Translational Medicine reports that 3D printed stents do help optimize bone regeneration in patients.  In the medical field, the treatment of large bone defects or injuries remains a thorny area.People who have severe defects in the upper or lower extremities due to infection, cancer or trauma often have to undergo amputation as it is difficult to regrow or repair more than one A little bone tissue. One existing treatment involves the manufacture of customized bone grafts from the patient's own bone tissue, although the success rate is not high and according to a recent report, a customized 3D-printed titanium mesh stent may be a potential solution Program, because implants can promote and achieve natural bone regeneration. A team at the Charité Musculoskeletal Surgery Center has demonstrated that it is possible to design and manufacture customized 3D-printed stents for the treatment of large bone defects. Using CT scans of the patient's bones, the medical team can generate 3D models of the defect's bones. Based on this digital model, a custom scaffold can be 3D modeled, then sent to a mechanism that uses a laser to sinter the 3D printer and use a medical grade titanium to make the scaffold.The resulting product is a 3D printed titanium implant with its Known for its porous scaffolding structure. This 3D printed structure is crucial for promoting bone regeneration as it allows the physician to fill the implant with the patient's bone tissue, growth factors and bone replacement material.It is noteworthy that the 3D printed mesh structure has been mechanically optimized, To 'further strengthen the healing process'. As Dr. Anne-Marie Pobloth, a veterinarian at the Julius Wolff Institute in Charité, explains: 'My team started using computer modeling techniques to optimize standard-size stents. Using a large animal model, we can examine how it works for bone regeneration The actual impact. Since the process of bone regeneration is very similar to that of humans, we can infer the healing of human bones. So far, the Charité Musculoskeletal Surgery Center has implanted a customized 3D printed bone scaffold into a total of 19 patients, all of which show promising results.3D imprinted implants themselves are characterized by a honeycomb structure , Constructed to create small channels that promote and guide bone regeneration.Importantly, the researchers found that they could change the stiffness of the implant by changing the diameter of the pillars of the honeycomb structure, enabling them to test the effectiveness of different stiffness. Dr. Georg N. Nuda, Director of the Biomechanics and Skeletal Muscle Regeneration Center at Julius Wolff, said: 'We think that bone regeneration will vary depending on the hardness of the stent being implanted, so in order to study the effect of mechanical stimulation during bone regeneration we used Four test sets accept implants of different stiffness. The results of these tests show that softer implants are more conducive to bone regeneration.Patient surgeon Dr. PF Philipp Schwabe explains: 'After three months of research, radiological evidence showed that soft implants were produced more than hard implants Faster mechanical stimulation to make bone grow faster. In fact, the researchers found that the biomechanical nature of the 3D printed implants directly affects the amount of bone formation and the quality of the regenerated bone, and based on this situation, the team is designing and producing a soft, mechanical-biological optimization using 3D printing technology Titanium mesh stent.The team said its technology can even be used to treat spine, oral and maxillofacial defects. Article Source: 3D Tiger |
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