High-Fu academicians jointly issued the latest article Zika vaccine development

Zika virus belongs to the genus Flaviviridae and is a major mosquito-borne pathogen. In 2015, the outbreak of Zika in Brazil rapidly spread in South America, Central and North America and further spread to more than 80 countries and regions. In February of this year, the first case of imported Zika was reported in our country.Zalica infection can cause neurological diseases such as Guillain-Barre syndrome in Guillain-Barre syndrome, which may lead to the development of microcephaly of the newborn in severe cases. Card virus can break through the blood-brain, blood-stained, blood-testis and blood-eye four major barrier of the human body by sexually transmitted .In February 2016 to November period, the World Health Organization announced the Zika virus and its caused neonatal microcephaly As an international public health emergency, there are no vaccines and effective treatments for this disease.

Beijing Academy of Biosciences, Beijing, Chinese Academy of Sciences Gao Fu co-operation group Pasteur Institute Shanghai Pasteur selected chimpanzee adenovirus vaccine development. Recombinant adenovirus vaccine has a strong immune capacity to maintain a long cycle, immune host wide without the need for adjuvants , Easy to be factory-produced and so on.Adiposomal 7 type 1 chimpanzee adenovirus (AdC7) pre-existing immunity in Chinese population is only 11.8%, much less than 74.2% of the commonly used human adenovirus type 5 (HuAd5) .Studies using molecular biology methods, The Zika virus M / E gene was cloned into the AdC7 vector and then the recombinant Ad-chimpanzee adenovirus vector vaccine AdC7-M / E was expressed which contained active Zika virus M / E protein. AdC7-M / E mice 1 week after activation can produce higher neutralizing antibodies, and for a long time to maintain a high level of neutralizing antibodies.

The vaccine can also activate a strong specific T cell response at the same time a needle immunization can completely protect immune-deficient mice from lethal doses of Zika virus infection and achieve the effect of scavenging immunity, that is, serum and target tissues and organs Were enough to detect the presence of viral RNA.Previously, the team reported in the Cell Zika virus infection in mice with immunodeficiency induced testicular tissue damage and atrophy, AdC7-M / E vaccine can protect the testes from damage The above results show that AdC7-M / E is an effective anti-Zika virus vaccine with clinical application prospects.In addition, the team developed an inactivated vaccine to prevent Zika virus infection last year and transferred it to Changchun Changsheng Biotechnology Co., Ltd. for follow-up development.

Relevant research results published in the JournalofVirology, Beijing Academy of Biosciences doctoral student Xu Kun, Shanghai Pasteur associate researcher Song Yufeng co-author, Gao Fu, Shanghai Pasteur researcher Zhou Dongming as co-author of the study. The Chinese Academy of Sciences strategic pilot science and technology training programs, the state's key research and development programs, major international science and technology projects, the Chinese Academy of Sciences international cooperation projects, the National Natural Science Foundation of innovative group projects funded.


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