Nano-titanium dioxide to enhance the genotoxic effects of trivalent arsenic mechanism diagram
As the typical representative of the family of nano-metal oxide materials, nano-titania has been widely used in the fields of materials, energy, electronics, biomedicine and other fields as early as commercial production. In recent years, nano-titania has been widely used in the fields of large specific surface area and higher surface Reactivity, showing unique advantages in the enrichment, removal and detection of pollutants.With the increasing production and demand of nano-sized titanium dioxide, the environmental release behavior and the potential interaction with pollutants have attracted much attention now.However, The interaction between nano-titania and pollutants is still unclear. The influence and mechanism of nano-titania on the environmental behavior and bioavailability of pollutants remains to be further studied.
Xu An Research Group of Institute of Technical Biology and Agricultural Engineering, Hefei Institute of Material Science, Chinese Academy of Sciences and Xu-Ping Zhao group focused on the environment around the wide distribution, strong toxicity of trivalent arsenic, the use of high sensitivity in vitro gene mutation detection of human and mouse hybridoma mammals Cell (AL cell) model in the interpretation of nano-titanium dioxide and trivalent arsenic compound genotoxicity and mechanism of progress made.The relevant research results published in Nanotoxicology.
The results show that the trivalent arsenic is attached to the nano-sized titanium dioxide agglomerates by competing with hydroxyl groups on the surface of the nano-titania to increase the agglomeration degree of the nano-sized titanium dioxide, and at the same time, the presence of the nano-sized titanium dioxide helps the arsenic enter the intracellular nano- In their own non-toxic conditions, can significantly increase arsenic-induced genotoxicity of AL cells.Further studies have shown that the genetic toxicity of nano-titanium dioxide to enhance arsenic is closely related to its pathway to carry arsenic into cells, and mitochondria as an important target organ of pollutants in Mediated nano-titanium dioxide enhance arsenic genotoxicity plays a key role in the study revealed the nano-titanium dioxide to enhance the genotoxicity of trivalent arsenic genotoxicity and cell-level response process, in order to fully evaluate the release of nano-titanium dioxide and other pollutants into the environment The co-existence of potential environmental and health risks provides new experimental evidence and ideas.
The research work was supported by the National Key Basic Research and Development Program (973 Program), the Chinese Academy of Sciences Strategic Leader Science and Technology Project B, the National Natural Science Foundation of China, and the Hefei Research Institute Special Fund.
