Angelica Angelica has a long history of analgesic use, and is often used in combination with herbs such as windbreak, Notopterygium, Myrrh, etc. Recently, the Chinese Academy of Traditional Chinese Medicine Research Institute of Chinese Academy of Traditional Chinese Medicine showed that Angelica decoction combined with volatile oil has a good analgesic effect.
The researchers divided 60 mice into blank control group, positive control codeine group and experimental drug Angelica dahuricae group. Rats in each group were given gavage with different doses of medicine or equal volume of water for 7 consecutive days, The experimental method investigated the analgesic effect of Angelica dahuricae in mice: First, through the hot-plate method, on the hot metal plate with constant temperature (55 ℃ ± 0. 5 ℃) Foot, by measuring the time from placing the mouse on the hot plate to licking the foot to determine its pain threshold to determine the analgesic effect of the drug. Second, by injecting mice with a certain concentration of glacial acetic acid, induced pain stimulus , Resulting in writhing reaction in mice within 15 minutes after injection to determine the number of writhing animal pain threshold compared with the blank control group Angelica and codeine mice licking time was significantly extended, The number of writhing decreased, showing a significant analgesic effect.
The results show that Angelica Angelica can reduce the pain conduction through the central nervous system to play an analgesic effect, especially for mild to moderate pain, the effect comparable to codeine, the researchers said the study for the clinical use of Angelica dahurica Data support.
