Inositol, also known as muscle sugar, cyclohexanol, and fibrin, is widely distributed in animals and plants and is an animal and microbial growth factor. Inositol has now been incorporated into the USP40-NF35, (BP2017), European Pharmacopoeia (EP9.0) and Korean Pharmacopoeia (10th Edition), etc. In recent years, the demand for inositol in domestic and overseas markets has been continuously increasing. The production and sales of inositol in our country have been steadily rising.
Approval of the situation
At present, there are dozens of inositol producers throughout the country, with an annual capacity of 10,000 tons and an annual output of over 8,000 tons. It has become the largest manufacturer and supplier of inositol in the world.
Official data show that as of June 21, 2017, a total of 195 inositol drug production approval numbers were issued nationwide, of which 7 were approved for the production of APIs. The manufacturing enterprises were: Haotian Pharmaceutical Co., Ltd., Zhucheng, Shandong, Peking University Pharmaceutical Chongqing Daxin Pharmaceutical Co., Ltd., Sichuan Xieli Pharmaceutical Co., Ltd., Henan Qinyang Pharmaceutical Factory, Hunan Jianlang Pharmaceutical Co., Ltd., Mudanjiang Hi-Tech Biochemical Co., Ltd., Beijing Taiyang Pharmaceutical Co., Ltd. The main products are: Shandong Zhucheng Haotian Pharmaceutical Co., Ltd., Henan Qinyang Pharmaceutical Factory.
Shandong Zhucheng Haotian Pharmaceutical Co., Ltd. is the original Zhucheng Xingmao Corn Co., Ltd. inositol plant development, after decades of development, has now become the country and the world's largest manufacturer of inositol, inositol 6000 tons. The company has passed the Chinese GMP certification, the US USP certification, HACCP certification, the EU FAMI-QS certification, the current production of inositol exports.
Henan Qinyang Pharmaceutical Factory has more than 20 years inositol production and R & D experience, is currently home to two GMP-accredited inositol manufacturers, with an annual output of more than 800 tons of inositol, can be divided into drugs, food, feed, etc. Level, content of more than 99%, products meet the NF, FCC, EP, BP and other standards.
As of June 21, 2017, a total of 188 inositol preparations were approved in the country, involving more than 100 manufacturers, including inositol tablets, inositol nicotinate tablets, inositol nicotinate ointment, lysostaphin Victoria B12 oral solution, compound three-dimensional linoleic acid capsules I, lysine dimensional B12 particles, compound procaine hydrochloride tablets, etc. More approved number of formulations products: inositol nicotinate tablets (142 Approval number), inositol tablets (24 approval number).
Export rose
Over the years, China's inositol has been exported, the export volume accounted for a large part of the current production. Into the 21st century, China's exports of inositol steadily. In 2000, China's exports of 1,400 tons of inositol; 2004, exports reached 2,000 Ton; In 2006, the export volume was 2,400 tons; In 2009, the export volume reached 2,600 tons. In recent years, due to the strong global market demand of inositol, China's exports increased rapidly. In 2010, the export volume exceeded 3,000 tons mark, reaching 3300 tons; in 2013, the export volume was 3600 tons; in 2014, the export exceeded 4,000 tons, 4200 tons; in 2015, the export volume reached 4450 tons, the export amount was 35.86 million dollars.In 2016, China's inositol export An amount of 4836 tons, an increase of 8.67% over the previous year, a record high, the export amount of 30.79 million US dollars, down 14.1% from 2000 exports of 1400 tons to more than 4800 tons now, China's annual exports of inositol The growth rate reached nearly 2 digits.
In recent decades, the export price of myo-inositol in our country fluctuated with a large margin, with the major export destinations in Asia, Europe and North America, and the inositol exported to the three regions accounted for 90% of the total exports. And other developed countries are the main destinations of myo-inositol export in China, inositol exported to the United States accounts for about 20% of China's total exports.In recent years, China's exports of inositol to India and Southeast Asian countries continue to increase, accounting for More and more.At present, there are more than 120 units in China engaged in the export of inositol, both inositol producers, there are many traders, including more than 110 private enterprises, accounting for the vast majority of major export enterprises: Qingdao Sheng Trading Co., Ltd., DSM Vitamin Trade Co., Ltd., Shandong Zhucheng Haotian Pharmaceutical Co., Ltd., Jinan Yinghua Yong Import and Export Trade Co., Ltd., Jilin sea biological engineering technology Co., Ltd. and so on.
Technological innovation
Inositol traditional production methods for the pressurized hydrolysis method.In recent years, people on the inositol production process a number of improvements, improvement and innovation.
Not long ago, sodium phytate was hydrolyzed, and Jilin Chemical Engineering Institute developed a new process that uses corn steep water as raw material to produce sodium phytate by ion exchange resin adsorption method, and then produces inositol by pressurized hydrolysis reaction. , Co-production of disodium hydrogen phosphate, its production of about 12 times the production of inositol, the effective recovery of organic phosphorus in grain, agricultural and sideline products for organic phosphorus recovery opened up a new way.
Atmospheric pressure catalytic method In recent years, China has recently developed and put into industrial production of atmospheric pressure catalytic method is a new method for the production of inositol, its hydrolysis and refining are unique: First, significantly reduce the one-time investment in equipment, The same size can save more than 50% of equipment investment; Second, the use of catalyst Feitian hydrolysis to shorten the production cycle, improve the utilization of raw materials; Third, the refining process has been improved, product quality and yield can be improved. Technical Research Institute of atmospheric pressure catalytic process developed as follows: a certain concentration of Ting Ting solution under normal pressure by adding a certain percentage of catalyst, heated hydrolysis, hydrolysis, filtration, crystallization, drying and other processes, inositol can be obtained. Because of its own characteristics of the catalyst, inositol can be a one-time crystallization, and access to higher quality finished products, thus simplifying the process and achieve the catalyst recycling.
Chemical synthesis method There are also companies start chemical production of inositol, completely out of the traditional mode of production of inositol follow: that is, the use of bran, bran, corn soak waste (through acid leaching) → phytic acid or calcium phytate , Sodium phytate (pressurized hydrolysis) → inositol.
Production practice shows that, per ton of glucose (100%), the average production of inositol 0.6t or so, product quality in line with the United States Pharmacopoeia prescribed indicators; product structure analysis and physiological activity is also consistent with the natural extract.
Publication No. CN136767A published Chinese patent application publication specification also published glucose in raw materials for the production of inositol: glucose as raw material, in the reactor by adding ethanol and boric acid complexation reaction, the end of the complexation reaction of ethanol recovery Re-use; complexed liquid into the reactor has been added sodium nitrite and glacial acetic acid oxidation, and then by the ring and ring closure treatment, hydrolysis and then add copper sulfate precipitation, acidification and; into the filter The filtrate filtered by the machine enters into a crystallization kettle and is concentrated and crystallized. Finally, the mixture is distirped by distillation, decolorized by adding activated carbon, crystallized twice, dehydrated and separated, and dried and crushed to obtain a finished product.
Prospects are good
The future of myoinositol production and marketing prospects will remain very optimistic, there are two main reasons.
First, the field of application is gradually expanding, the market demand continues to increase.Insulin is used in a wide range of purposes, it has the role of metabolic fat and cholesterol, for the treatment of hepatitis, cirrhosis, fatty liver and hypercholesterolemia in the blood.It can also promote In addition, inositol also plays an important role in the nutrition of brain cells. Inositol is also a kind of 'biosynthesis' which participates in the body's metabolic activity, With immune, prevention and treatment of certain diseases and other effects.
In recent years, people have found many new uses of inositol, applications continue to expand.Such as: chemical synthesis of paclitaxel, its cancer effect is poor, but with inositol to be modified, the cancer effect will be better than natural products, This has become a new point of consumption of inositol in the pharmaceutical industry today.Fluoroinositol is a new product developed in recent years with anti-cancer, cancer-fighting and high-efficiency immune function.It will be in-depth processing of inositol can be made into muscle Alcohol methyl ether, inositol peptides and other products, in the pharmaceutical, chemical and other industries have great practical value.In addition, it was also found that inositol and sarcoma can make fat into heat consumed, so inositol Weight-loss lipid-lowering diet and nutraceutical products popular in Europe and the United States, and the future demand will continue to rise.
Second, there are many favorable factors for the development of myo-inositol industry in our country. At present, inositol production is mostly made from rice bran cake as raw material, and China is a big rice-producing country in the world with very rich sources of raw materials. In addition, Of the industrial base, the company's production technology is more mature, experienced operators, lower production costs, quality and stability in the international market, the product has a certain comparative advantage is expected in the future inositol industry in China will have a broader space for development.
