Xi'an, China - 2017 China Pharmaceutical Congress 2017 and the 17th Chinese Pharmacist Week, hosted by the Chinese Pharmaceutical Association, Shaanxi Provincial Pharmaceutical Association and the Air Force Military Medical University, were held on November 8 to 6, Xi'an was held on the theme of "promoting the innovation and development of pharmacy, a total of a healthy dream of China," as the theme, attracting more than 2,000 experts and scholars from the fields of medicine, health, medicine and related fields to participate in. The two-day meeting covers the pharmacy Research in all fields, discussed the development status and prospects of various disciplines, to promote the development of pharmaceutical industry, building a healthy contribution to China.
Waters Corporation, a leading analytics partner in the industry, is fully involved in the event and brings with it a range of innovative and efficient drug analysis solutions. Many senior scientists from home and abroad introduced Waters Recent developments in pharmaceutical research, including biopharmaceuticals, Chinese medicine, pharmaceuticals, and omics for the discovery of drug targets, have attracted the attention of participants.
Dr. Jose Castro-Perez, Waters Scientific Marketing Director, introduces the latest analytical techniques
Jose Castro-Perez, Ph.D., director of health sciences at Waters Corporation, introduced the most advanced SONAR technology in data-independent acquisition and its applications in metabolomics and proteomics sample analysis, demonstrating the high sensitivity, High selectivity.Moreover, Dr. Jose also introduced the principle and application of the current hot ionization technology DESI and REIMS to the participants, which attracted the attention of experts and scholars.
Guo Tian, Senior Application Scientist, Waters Introduces Use of UPLC / ACQUITY Qda Solution for Peptide Drug Separation Analysis Problems
Peptide drug research is a hot area in the pharmaceutical industry in recent years. A senior applied scientist at Waters, Guo Tian, introduced the problem of using UPLC / ACQUITY QDa detector to solve the problem of separation and analysis of polypeptide drugs. The combination of LC-UV-MS The practicality and reliability of workflows facilitate the rapid screening of impurities in synthetic peptide samples.
Dr. Edward Chen, Senior Applications Specialist, Asia Pacific, Waters Introduces Protein Characterization Program Based on LC-MS
Dr. Chen Xi, senior applied expert of Asia Pacific, Waters Asia, introduced the protein characterization scheme based on LC-MS for biopharmaceutical industry. From molecular weight analysis, peptide map analysis and glycosylation analysis of UNIFI platform to Progenesis / PLGS platform for host cell residual protein analysis, as well as the Hydrogen-Deuterium Exchange Mass Spectrometry of the DynamX platform for the analysis of protein high-order structures. Waters offers a complete platform solution and shows specific applications in bio-analog analysis.
Chen Jing, Product Manager, Waters Division, Describes Application of UPLC Technology in Pharmaceutical Quality Control
From the early phase of drug development to the latter part of the drug quality control can not be separated from the use of liquid chromatography, Waters separation product manager Chen Jing UPLC technology introduced in the quality control of drugs. UPLC better separation capacity Impurities analysis of biopharmaceutical products is of great importance to help pharmaceutical companies get better resolution in less time, improve experimental efficiency and reduce operating costs.
Dr. Zuo Zhiguo, senior scientist of Waters Corporation, introduced the application of QDa in N-glycan analysis of protein drugs
Glycosylation is crucial for proteinaceous drugs. Dr. Han Zhiguo, a senior scientist from Waters Corporation, introduced the application of RFMS combined with QDa mass spectrometer in the N-glycan analysis of protein drugs. Through the application cases The new N-glycan labeling reagent is shown to greatly improve the N-glycan analysis efficiency. When the QDa tandem mass spectrometry detector is used, qualitative and quantitative N-glycan analysis can be carried out at the same time, which is very useful in the initial drug development and in the method transfer Sexuality and reliability.
Wang Xiaoxia, Senior Application Scientist, Waters Corporation Introduces the Quantitative Analysis Method for Establishing Monosaccharides, Disaccharides and Sugar Alcohols Using H-Class / QDa LC / MS System
Wang Xiaoxia, a senior applied scientist at Waters China, introduced the quantitative analysis method of monosaccharides, disaccharides and sugar alcohols with ACQUITU UPLC H-Class / QDa LC / MS system, which can quickly separate monosaccharides and disaccharides Isomers for good separation, and the use of QDa mass spectrometry detector significantly increased the detection sensitivity can be used to analyze the Chinese medicine Dali pill or food monosaccharide and disaccharide content, for the quality control of drugs or food Quantitative Analysis of Monosaccharides and Disaccharides.
TA Instruments Dr. Ming-Shen Lin introduced the application of micro-thermal analysis in biopharmaceuticals
Dr. Liming Shen from TA Instruments (a wholly owned subsidiary of Waters Corporation) introduced the application of microcalorimetry in biopharmaceuticals. In view of the instrumental principle and actuality of isothermal titration calorimeter ITC and differential scanning calorimeter Nano DSC The application case is briefly described: ITC is useful for characterizing molecular interactions, NanoDSC can measure the stability of proteins and other molecules, identify high-affinity ligand-binding reactions, and deconvolve multidomain structures.
In addition to the excellent professional reports, Waters also hosted a new ACQUITY QDa live demo during the conference to show UPLC / QDa applications in biopharmaceuticals, small molecule pharmaceuticals and Chinese medicine from data acquisition to data processing, ACQUITY UPLC / QDa showed a good stability, access to participants widely recognized.
Waters Applications Scientist Live Demo QDa
The ACQUITY QDa is a new mass spectrometry detector that, in conjunction with ACQUITY UPLC, PDA, will have everything needed to isolate, quantify and identify compounds. QDa adds mass spectrometry capabilities to existing chromatography workflows to reduce process monitoring costs. Genuine The introduction of MS into the QC of pharmaceuticals has been widely used in chemical pharmacy, biopharmaceuticals, and important analytical work.